How ZENPEP® works

Couple enjoying a slice of pizza Not actual patients.

ZENPEP is a pancreatic enzyme replacement therapy, which is a type of prescription medicine for people who can’t digest food normally because their pancreas doesn’t make enough enzymes

ZENPEP helps improve your ability to digest and absorb the nutrients you need from the food you eat, which may help relieve some exocrine pancreatic insufficiency (EPI) symptoms.

In clinical studies, people with EPI associated with cystic fibrosis absorbed more fat from foods when using ZENPEP than those using a placebo (sugar pill).

Each ZENPEP capsule contains a mix of enzymes known as lipase, protease, and amylase to replace
those the pancreas can’t provide. These enzymes have a few purposes:

  • To digest fats, proteins, and carbohydrates (3 components of food that supply calories)
  • To help absorb nutrients, which can help relieve the symptoms of EPI
Lipase, protease, and amylase in a capsule Lipase, protease, and amylase in a capsule
  • Each ZENPEP capsule is always taken with a meal or snack so it enters your digestive system at the same time as your food
  • ZENPEP capsules release enzymes to help digest food

Did you know that without enough pancreatic enzymes, you may continue to experience EPI symptoms?

It’s important to take enough enzymes to control symptoms. The most common reason for treatment failure is not getting enough enzymes or not taking
them at the right time. ZENPEP offers 8 flexible dosing strengths, ranging from 3K to 60K lipase units per capsule, which help meet your individual EPI
management needs.

Capsules representing ZENPEP strengths: 3K, 5K, 10K, 15K, 20K, 25K, 40K, 60KCapsules representing ZENPEP strengths: 3K, 5K, 10K, 15K, 20K, 25K, 40K, 60K

Not actual capsule images. K=1,000. 

To help ensure you get the enzymes you need, ZENPEP 60K can offer a starting dose with more enzymes in a single high-strength capsule than other treatment options.